Folate:Active B12
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
146.869451
|
1
|
<0.0001
|
***
|
|
folate_Active.B12
|
3.973972
|
1
|
0.05
|
ns
|
|
Study
|
7.725711
|
1
|
0.005
|
**
|
|
GA_samp
|
80.489628
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
6.300094
|
1
|
0.01
|
*
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
26.4615227
|
1
|
<0.0001
|
***
|
|
folate_Active.B12
|
0.5606844
|
1
|
0.5
|
ns
|
|
Study
|
12.9049475
|
1
|
0.0003
|
***
|
|
GA_samp
|
1318.5704897
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
3.2107060
|
1
|
0.07
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
246.688649
|
1
|
<0.0001
|
***
|
|
folate_Active.B12
|
1.758414
|
1
|
0.2
|
ns
|
|
Study
|
1.272412
|
1
|
0.3
|
ns
|
|
GA_samp
|
619.142889
|
1
|
<0.0001
|
***
|
|
folate_Active.B12:Study
|
1.405998
|
1
|
0.2
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
1.861
|
1.861
|
0.2
|
ns
|
|
3
|
Study
|
1
|
Inf
|
4.575
|
4.575
|
0.03
|
*
|
|
4
|
GA_samp
|
1
|
Inf
|
0.008
|
0.008
|
0.9
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
0.769
|
0.769
|
0.4
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
2.240
|
2.240
|
0.1
|
ns
|
|
3
|
Study
|
1
|
Inf
|
10.426
|
10.426
|
0.001
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.075
|
0.075
|
0.8
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
0.861
|
0.861
|
0.4
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_Active.B12
|
1
|
Inf
|
8.943
|
8.943
|
0.003
|
**
|
|
3
|
Study
|
1
|
Inf
|
76.835
|
76.835
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
1.630
|
1.630
|
0.2
|
ns
|
|
2
|
folate_Active.B12:Study
|
1
|
Inf
|
0.099
|
0.099
|
0.8
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
18.89 (11.75, 30.37)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.05
|
|
StudySTOP
|
0.79 (0.68, 0.93)
|
0.006
|
|
GA_samp
|
1.14 (1.11, 1.18)
|
<0.0001
|
|
folate_Active.B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.01
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.95 (1.52, 2.50)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.52
|
|
StudySTOP
|
1.13 (1.04, 1.21)
|
0.002
|
|
GA_samp
|
1.33 (1.31, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.07 (0.05, 0.10)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.47
|
|
StudySTOP
|
0.97 (0.88, 1.07)
|
0.55
|
|
GA_samp
|
1.31 (1.28, 1.33)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
16.48 (8.93, 30.43)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.23
|
|
StudySTOP
|
0.74 (0.61, 0.89)
|
0.002
|
|
GA_samp
|
1.00 (0.96, 1.04)
|
0.92
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
4.49 (2.33, 8.67)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.19
|
|
StudySTOP
|
0.63 (0.51, 0.77)
|
<0.0001
|
|
GA_samp
|
0.99 (0.95, 1.04)
|
0.79
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.11 (5.35, 6.99)
|
<0.0001
|
|
folate_Active.B12
|
1.00 (1.00, 1.00)
|
0.003
|
|
StudySTOP
|
0.85 (0.83, 0.88)
|
<0.0001
|
|
GA_samp
|
0.99 (0.98, 1.00)
|
0.20
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:Active B12 ratio and may be misleading when interaction term is involved.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
103.60903
|
8.502238
|
94.11762
|
88.0314
|
121.9432
|
|
STOP
|
92.11878
|
7.303106
|
82.09510
|
78.6785
|
107.8550
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
93.00782
|
2.717590
|
191.0850
|
87.79903
|
98.52562
|
|
STOP
|
104.70916
|
2.911584
|
154.5832
|
99.11265
|
110.62169
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.427344
|
0.0799604
|
354.2074
|
2.275072
|
2.589806
|
|
STOP
|
2.353628
|
0.0710247
|
276.0152
|
2.217881
|
2.497683
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
16.23155
|
1.0039454
|
Inf
|
14.37844
|
18.32348
|
|
STOP
|
11.98054
|
0.6055347
|
Inf
|
10.85060
|
13.22814
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.966494
|
0.2641498
|
Inf
|
3.481135
|
4.519525
|
|
STOP
|
2.493776
|
0.1339340
|
Inf
|
2.244614
|
2.770595
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.555065
|
0.0631408
|
Inf
|
5.432679
|
5.680207
|
|
STOP
|
4.736358
|
0.0530073
|
Inf
|
4.633597
|
4.841399
|
Comparisons
Effect for every 500 unit increase in Folate:Active B12 ratio.
|
Hormone
|
Contrast
|
Study
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
0.96 (0.93, 1.00)
|
0.05
|
|
PRL (ng/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
1.03 (0.99, 1.07)
|
0.1
|
|
hPL (μg/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
1.00 (0.98, 1.01)
|
0.5
|
|
hPL (μg/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
1.00 (0.98, 1.01)
|
0.5
|
|
GH2 (ng/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
0.99 (0.97, 1.01)
|
0.5
|
|
GH2 (ng/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
0.99 (0.97, 1.01)
|
0.5
|
|
Insulin (uU/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
0.98 (0.94, 1.01)
|
0.2
|
|
Insulin (uU/ml)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
0.98 (0.94, 1.01)
|
0.2
|
|
HOMA-IR
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
0.97 (0.93, 1.01)
|
0.2
|
|
HOMA-IR
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
0.97 (0.93, 1.01)
|
0.2
|
|
Glucose (mmol/L)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
SCOPE
|
0.99 (0.99, 1.00)
|
0.003
|
|
Glucose (mmol/L)
|
folate_Active.B121123.57 / folate_Active.B12623.57
|
STOP
|
0.99 (0.99, 1.00)
|
0.003
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
